STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (152 aa)    
Predicted Functional Partners:
ribE
Riboflavin synthase, alpha subunit; Identified by similarity to SP:P51961; match to protein family HMM PF00677; match to protein family HMM TIGR00187.
 
 0.999
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Belongs to the DHBP synthase family.
 
 
 0.995
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
 
 0.991
nusB
N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
 
  
 0.986
yidC
Inner membrane protein, 60 kDa; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
    
 0.906
metK
S-adenosylmethionine synthetase; Identified by similarity to SP:P04384; match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family.
  
 
 0.884
APH_0058
S-adenosylmethionine synthetase, truncated; Identified by similarity to SP:P04384; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family.
  
 
 0.884
ribA
GTP cyclohydrolase II; Identified by similarity to SP:P43525; match to protein family HMM PF00925.
  
  
 0.876
APH_1319
GTP cyclohydrolase II, degenerate; Peptides match to this protein was detected in human HL-60 cells by global proteomic analysis.
  
  
 0.876
rplU
Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
    0.842
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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