STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APH_0659Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578. (203 aa)    
Predicted Functional Partners:
trxB
Thioredoxin-disulfide reductase; Identified by similarity to SP:P09625; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292.
  
 
 0.978
APH_0141
Putative thiol:disulfide oxidoreductase; Identified by similarity to SP:P33926.
  
 0.942
APH_0561
Putative thiol-disulfide oxidoreductase; Identified by similarity to SP:P35160.
  
 0.942
APH_1280
Hypothetical protein; Identified by Glimmer2; putative.
  
 0.939
APH_0734
Pyridine nucleotide-disulfide oxidoreductase family protein; Identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992.
  
 
 0.896
trx
Thioredoxin; Identified by similarity to SP:P00274; match to protein family HMM PF00085; match to protein family HMM TIGR01068; Belongs to the thioredoxin family.
  
 
 0.798
sodB
Fe superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.698
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 0.679
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
   
 
 0.658
APH_0492
Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.584
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.