STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APH_0814GTP cyclohydrolase I; Identified by similarity to SP:Q54769; match to protein family HMM PF01227; contains internal deletion; Belongs to the GTP cyclohydrolase I family. (166 aa)    
Predicted Functional Partners:
ribA
GTP cyclohydrolase II; Identified by similarity to SP:P43525; match to protein family HMM PF00925.
   
 
 0.906
APH_1319
GTP cyclohydrolase II, degenerate; Peptides match to this protein was detected in human HL-60 cells by global proteomic analysis.
   
 
 0.906
folE
GTP cyclohydrolase I; Identified by similarity to SP:P19465; match to protein family HMM PF01227.
  
  
 
0.900
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by similarity to SP:P29252; match to protein family HMM PF01288; match to protein family HMM TIGR01498.
  
  
 0.832
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
  
 0.832
folB
Dihydroneopterin aldolase; Identified by similarity to SP:P46362; match to protein family HMM PF02152; match to protein family HMM TIGR00526.
  
  
 0.832
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
  0.832
APH_0813
ATP synthase F1, gamma subunit, truncated; Identified by match to protein family HMM PF00231.
  
    0.786
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.591
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
   0.506
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.