Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pleCSensor histidine kinase PleC; Name change according to the cited literature. PMID: 16882029. (470 aa)    
Predicted Functional Partners:
pleD
Response regulator/GGDEF domain protein PleD; Name change according to the cited literature. PMID: 16882029.
 0.999
ctrA
DNA-binding response regulator CtrA; Name change according to the cited literature. PMID: 16882029.
 
 0.978
APH_0433
Conserved domain protein.
   
 0.809
APH_1308
Putative pyruvate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
    
 0.780
cycM
Cytochrome C, membrane-bound; Identified by similarity to SP:P30323; match to protein family HMM PF00034.
    
 
 0.755
prsA
Ribose-phosphate pyrophosphokinase; Identified by similarity to SP:P08330; match to protein family HMM PF00156; match to protein family HMM TIGR01251.
    
 0.750
cckA
Sensor histidine kinase/response regulator CckA; Name change according to the cited literature. PMID: 16882029.
 
 
0.728
ntrX
Response Regulator NtrX, putative nitrogen assimilation regulatory protein; Name change according to the cited literature. PMID: 16882029.
 
 
 0.631
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 0.628
sucB
2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM TIGR01347.
    
 0.615
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.