node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APH_0541 | ffh | APH_0541 | APH_0349 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | 0.932 |
APH_0541 | ftsY | APH_0541 | APH_1227 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Signal recognition particle-docking protein FtsY; Identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064. | 0.927 |
APH_0541 | secA | APH_0541 | APH_1178 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.948 |
APH_0541 | secB | APH_0541 | APH_0097 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. | 0.921 |
APH_0541 | secD | APH_0541 | APH_1366 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.892 |
APH_0541 | secE | APH_0541 | APH_1030 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.958 |
APH_0541 | secG | APH_0541 | APH_0039 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.972 |
APH_0541 | secY | APH_0541 | APH_0299 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.972 |
APH_0541 | yajC | APH_0541 | APH_1090 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.922 |
APH_0541 | yidC | APH_0541 | APH_0540 | Putative membrane protein; Identified by match to protein family HMM PF02096. | Inner membrane protein, 60 kDa; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.900 |
ffh | APH_0541 | APH_0349 | APH_0541 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Putative membrane protein; Identified by match to protein family HMM PF02096. | 0.932 |
ffh | ftsY | APH_0349 | APH_1227 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Signal recognition particle-docking protein FtsY; Identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064. | 0.999 |
ffh | secA | APH_0349 | APH_1178 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.953 |
ffh | secB | APH_0349 | APH_0097 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. | 0.940 |
ffh | secD | APH_0349 | APH_1366 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.444 |
ffh | secE | APH_0349 | APH_1030 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.978 |
ffh | secG | APH_0349 | APH_0039 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.976 |
ffh | secY | APH_0349 | APH_0299 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.988 |
ffh | yajC | APH_0349 | APH_1090 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.941 |
ffh | yidC | APH_0349 | APH_0540 | Signal recognition particle protein; Identified by similarity to SP:P07019; match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959. | Inner membrane protein, 60 kDa; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.932 |