guaA protein (Anaplasma phagocytophilum) - STRING interaction network

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guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP. (529 aa)

Predicted Functional Partners:

guaB

0.999

pyrG

0.968

gmk

0.963

surE

0.962

rplK

0.960

APH_0564

0.959

argS

0.959

APH_0552

0.958

APH_0147

0.957

map

0.952

Your Current Organism:

Anaplasma phagocytophilum

NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH_0147	gmk	APH_0147	APH_0170	Guanylate kinase, truncated; Identified by similarity to SP:P60548.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.900
APH_0147	guaA	APH_0147	APH_1233	Guanylate kinase, truncated; Identified by similarity to SP:P60548.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.957
APH_0147	guaB	APH_0147	APH_0088	Guanylate kinase, truncated; Identified by similarity to SP:P60548.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.556
APH_0147	surE	APH_0147	APH_0524	Guanylate kinase, truncated; Identified by similarity to SP:P60548.	Stationary-phase survival protein SurE; Identified by similarity to SP:P36664; match to protein family HMM PF01975; match to protein family HMM TIGR00087.	0.900
APH_0552	guaA	APH_0552	APH_1233	Putative twin-arginine translocation protein TatB; Identified by similarity to SP:O69415; match to protein family HMM PF02416.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.958
APH_0564	guaA	APH_0564	APH_1233	arginyl-tRNA synthetase, degenerate; Peptides match to this protein was detected in human HL-60 cells by global proteomic analysis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.959
APH_0564	pyrG	APH_0564	APH_0038	arginyl-tRNA synthetase, degenerate; Peptides match to this protein was detected in human HL-60 cells by global proteomic analysis.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.776
APH_0564	rplK	APH_0564	APH_1028	arginyl-tRNA synthetase, degenerate; Peptides match to this protein was detected in human HL-60 cells by global proteomic analysis.	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.429
argS	guaA	APH_0700	APH_1233	arginyl-tRNA synthetase; Identified by similarity to SP:P46906; match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.959
argS	pyrG	APH_0700	APH_0038	arginyl-tRNA synthetase; Identified by similarity to SP:P46906; match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.776
argS	rplK	APH_0700	APH_1028	arginyl-tRNA synthetase; Identified by similarity to SP:P46906; match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456.	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.429
gmk	APH_0147	APH_0170	APH_0147	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Guanylate kinase, truncated; Identified by similarity to SP:P60548.	0.900
gmk	guaA	APH_0170	APH_1233	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.963
gmk	guaB	APH_0170	APH_0088	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.556
gmk	surE	APH_0170	APH_0524	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Stationary-phase survival protein SurE; Identified by similarity to SP:P36664; match to protein family HMM PF01975; match to protein family HMM TIGR00087.	0.900
guaA	APH_0147	APH_1233	APH_0147	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase, truncated; Identified by similarity to SP:P60548.	0.957
guaA	APH_0552	APH_1233	APH_0552	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Putative twin-arginine translocation protein TatB; Identified by similarity to SP:O69415; match to protein family HMM PF02416.	0.958
guaA	APH_0564	APH_1233	APH_0564	GMP synthase; Catalyzes the synthesis of GMP from XMP.	arginyl-tRNA synthetase, degenerate; Peptides match to this protein was detected in human HL-60 cells by global proteomic analysis.	0.959
guaA	argS	APH_1233	APH_0700	GMP synthase; Catalyzes the synthesis of GMP from XMP.	arginyl-tRNA synthetase; Identified by similarity to SP:P46906; match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456.	0.959
guaA	gmk	APH_1233	APH_0170	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.963