STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
APH_1271Cytochrome c-type biogenesis protein, CcmF/CycK/CcsA family; Identified by similarity to SP:P45403; match to protein family HMM PF01578. (637 aa)    
Predicted Functional Partners:
APH_0141
Putative thiol:disulfide oxidoreductase; Identified by similarity to SP:P33926.
 
  
 0.959
APH_0687
Cytochrome c biogenesis family protein; Possible subunit of a heme lyase.
 
  
 0.916
ccmE
Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.890
ccmC
Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.843
APH_1397
Putative heme exporter protein CcmB.
 
  
 0.701
ccmA
Heme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.558
APH_1270
Identified by match to protein family HMM PF01571; Belongs to the GcvT family.
       0.556
APH_0561
Putative thiol-disulfide oxidoreductase; Identified by similarity to SP:P35160.
  
  
 0.417
p44-16
Encodes a full-length P44 outer membrane protein.
       0.405
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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