STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
APH_1305Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P45522; match to protein family HMM PF00999; match to protein family HMM PF02254; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (571 aa)    
Predicted Functional Partners:
APH_1306
Conserved hypothetical protein; Identified by similarity to GB:AAS14896.1.
 
    0.950
nnrE
YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...]
  
  
 0.592
APH_1148
Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.
     
 0.592
fabI
Enoyl-(acyl-carrier-protein) reductase; Identified by similarity to SP:P54616.
     
 0.579
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.577
APH_1182
Potassium uptake protein, TrkH family; Identified by similarity to GB:BAA31229.1; match to protein family HMM PF02386; match to protein family HMM PF07723.
   
 
 0.567
APH_1303
comF family protein.
       0.563
mgtE
Magnesium transporter; Acts as a magnesium transporter.
     
 0.558
ihfB
Integration host factor, beta subunit; Identified by similarity to SP:Q06607; match to protein family HMM PF00216.
   
 
 0.550
gshB
Glutathione synthetase; Identified by similarity to SP:P04425; match to protein family HMM PF02951; match to protein family HMM TIGR01380; Belongs to the prokaryotic GSH synthase family.
  
  
 0.549
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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