| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTC_02047 | CTC_02553 | CTC_02047 | CTC_02553 | Dihydrolipoamide dehydrogenase. | Thioredoxin; Belongs to the thioredoxin family. | 0.874 |
| CTC_02047 | clpX | CTC_02047 | CTC_02374 | Dihydrolipoamide dehydrogenase. | ATP-dependent clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.833 |
| CTC_02047 | dnaJ | CTC_02047 | CTC_02030 | Dihydrolipoamide dehydrogenase. | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.668 |
| CTC_02047 | dnaK-2 | CTC_02047 | CTC_02031 | Dihydrolipoamide dehydrogenase. | Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.924 |
| CTC_02047 | groE | CTC_02047 | CTC_02413 | Dihydrolipoamide dehydrogenase. | 60 kDa chaperonin groEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.942 |
| CTC_02047 | grpE | CTC_02047 | CTC_02032 | Dihydrolipoamide dehydrogenase. | Putative grpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...] | 0.706 |
| CTC_02047 | guaB | CTC_02047 | CTC_02410 | Dihydrolipoamide dehydrogenase. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.842 |
| CTC_02047 | htpG | CTC_02047 | CTC_01489 | Dihydrolipoamide dehydrogenase. | Heat shock protein htpG; Molecular chaperone. Has ATPase activity. | 0.480 |
| CTC_02047 | ldh | CTC_02047 | CTC_01998 | Dihydrolipoamide dehydrogenase. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.950 |
| CTC_02047 | lon | CTC_02047 | CTC_02372 | Dihydrolipoamide dehydrogenase. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.791 |
| CTC_02553 | CTC_02047 | CTC_02553 | CTC_02047 | Thioredoxin; Belongs to the thioredoxin family. | Dihydrolipoamide dehydrogenase. | 0.874 |
| CTC_02553 | clpX | CTC_02553 | CTC_02374 | Thioredoxin; Belongs to the thioredoxin family. | ATP-dependent clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.491 |
| CTC_02553 | dnaJ | CTC_02553 | CTC_02030 | Thioredoxin; Belongs to the thioredoxin family. | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.532 |
| CTC_02553 | dnaK-2 | CTC_02553 | CTC_02031 | Thioredoxin; Belongs to the thioredoxin family. | Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.611 |
| CTC_02553 | groE | CTC_02553 | CTC_02413 | Thioredoxin; Belongs to the thioredoxin family. | 60 kDa chaperonin groEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.872 |
| CTC_02553 | grpE | CTC_02553 | CTC_02032 | Thioredoxin; Belongs to the thioredoxin family. | Putative grpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...] | 0.589 |
| CTC_02553 | htpG | CTC_02553 | CTC_01489 | Thioredoxin; Belongs to the thioredoxin family. | Heat shock protein htpG; Molecular chaperone. Has ATPase activity. | 0.413 |
| clpX | CTC_02047 | CTC_02374 | CTC_02047 | ATP-dependent clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Dihydrolipoamide dehydrogenase. | 0.833 |
| clpX | CTC_02553 | CTC_02374 | CTC_02553 | ATP-dependent clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Thioredoxin; Belongs to the thioredoxin family. | 0.491 |
| clpX | dnaJ | CTC_02374 | CTC_02030 | ATP-dependent clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.480 |
