node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGB20749.1 | AGB22152.1 | Mycsm_00294 | Mycsm_01760 | Molecular chaperone; PFAM: Hsp70 protein. | PFAM: Protein of unknown function (DUF2599). | 0.536 |
AGB20749.1 | AGB22540.1 | Mycsm_00294 | Mycsm_02187 | Molecular chaperone; PFAM: Hsp70 protein. | Deacetylase, histone deacetylase/acetoin utilization protein; PFAM: Histone deacetylase domain. | 0.491 |
AGB20749.1 | polA | Mycsm_00294 | Mycsm_03031 | Molecular chaperone; PFAM: Hsp70 protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.448 |
AGB21861.1 | AGB22152.1 | Mycsm_01450 | Mycsm_01760 | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | PFAM: Protein of unknown function (DUF2599). | 0.739 |
AGB21861.1 | AGB23436.1 | Mycsm_01450 | Mycsm_03121 | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | Hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.411 |
AGB21861.1 | guaB | Mycsm_01450 | Mycsm_01126 | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.620 |
AGB21861.1 | gyrB | Mycsm_01450 | Mycsm_00006 | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.868 |
AGB21861.1 | polA | Mycsm_01450 | Mycsm_03031 | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.998 |
AGB21861.1 | topA | Mycsm_01450 | Mycsm_05958 | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | DNA topoisomerase I, bacterial; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removi [...] | 0.999 |
AGB22151.1 | AGB22152.1 | Mycsm_01759 | Mycsm_01760 | Hypothetical protein. | PFAM: Protein of unknown function (DUF2599). | 0.732 |
AGB22152.1 | AGB20749.1 | Mycsm_01760 | Mycsm_00294 | PFAM: Protein of unknown function (DUF2599). | Molecular chaperone; PFAM: Hsp70 protein. | 0.536 |
AGB22152.1 | AGB21861.1 | Mycsm_01760 | Mycsm_01450 | PFAM: Protein of unknown function (DUF2599). | DNA/RNA helicase, superfamily I; PFAM: UvrD/REP helicase; HRDC domain. | 0.739 |
AGB22152.1 | AGB22151.1 | Mycsm_01760 | Mycsm_01759 | PFAM: Protein of unknown function (DUF2599). | Hypothetical protein. | 0.732 |
AGB22152.1 | AGB22540.1 | Mycsm_01760 | Mycsm_02187 | PFAM: Protein of unknown function (DUF2599). | Deacetylase, histone deacetylase/acetoin utilization protein; PFAM: Histone deacetylase domain. | 0.688 |
AGB22152.1 | AGB23436.1 | Mycsm_01760 | Mycsm_03121 | PFAM: Protein of unknown function (DUF2599). | Hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.705 |
AGB22152.1 | AGB25956.1 | Mycsm_01760 | Mycsm_05784 | PFAM: Protein of unknown function (DUF2599). | Hypothetical protein. | 0.569 |
AGB22152.1 | guaB | Mycsm_01760 | Mycsm_01126 | PFAM: Protein of unknown function (DUF2599). | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.570 |
AGB22152.1 | gyrB | Mycsm_01760 | Mycsm_00006 | PFAM: Protein of unknown function (DUF2599). | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.660 |
AGB22152.1 | polA | Mycsm_01760 | Mycsm_03031 | PFAM: Protein of unknown function (DUF2599). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.592 |
AGB22152.1 | topA | Mycsm_01760 | Mycsm_05958 | PFAM: Protein of unknown function (DUF2599). | DNA topoisomerase I, bacterial; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removi [...] | 0.567 |