Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (213 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 0.999
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.998
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.995
AGB23117.1
Shikimate-5-dehydrogenase, fungal AROM-type; PFAM: Shikimate dehydrogenase substrate binding domain; TIGRFAM: shikimate-5-dehydrogenase, fungal AROM-type; shikimate 5-dehydrogenase; manually curated; Belongs to the shikimate dehydrogenase family.
 
 
 0.991
AGB25421.1
PFAM: Shikimate dehydrogenase substrate binding domain; TIGRFAM: shikimate 5-dehydrogenase.
 
 0.991
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
 
  
 0.974
AGB26294.1
PFAM: Prephenate dehydrogenase; manually curated.
 
 
 0.898
pheA
PFAM: Prephenate dehydratase; ACT domain.
 
  
 0.821
AGB24143.1
PFAM: Class-II DAHP synthetase family; TIGRFAM: 3-deoxy-7-phosphoheptulonate synthase, class II.
    
 0.739
AGB23679.1
Chorismate mutase, putative; Catalyzes the Claisen rearrangement of chorismate to prephenate.
  
 
 0.719
Your Current Organism:
Mycobacterium sp. JS623
NCBI taxonomy Id: 212767
Other names: M. sp. JS623
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