AGB24605.1 protein (Mycobacterium sp. JS623)

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AGB24605.1

Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (537 aa)

Predicted Functional Partners:

AGB22594.1

0.940

ilvC

0.916

AGB22593.1

0.863

AGB20643.1

0.856

AGB23560.1

0.850

AGB21479.1

0.849

AGB25563.1

0.839

leuB

0.792

AGB23335.1

0.781

AGB23695.1

0.780

Your Current Organism:

Mycobacterium sp. JS623

NCBI taxonomy Id: 212767
Other names: M. sp. JS623

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGB20643.1	AGB21479.1	Mycsm_00182	Mycsm_01054	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.985
AGB20643.1	AGB22593.1	Mycsm_00182	Mycsm_02242	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.	0.983
AGB20643.1	AGB22594.1	Mycsm_00182	Mycsm_02243	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.	0.996
AGB20643.1	AGB23335.1	Mycsm_00182	Mycsm_03013	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.923
AGB20643.1	AGB23560.1	Mycsm_00182	Mycsm_03253	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.850
AGB20643.1	AGB23695.1	Mycsm_00182	Mycsm_03395	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Threonine dehydratase; PFAM: Pyridoxal-phosphate dependent enzyme.	0.930
AGB20643.1	AGB24605.1	Mycsm_00182	Mycsm_04360	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.856
AGB20643.1	AGB25563.1	Mycsm_00182	Mycsm_05372	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.984
AGB20643.1	ilvC	Mycsm_00182	Mycsm_02244	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.997
AGB20643.1	leuB	Mycsm_00182	Mycsm_02248	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Isocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.	0.979
AGB21479.1	AGB20643.1	Mycsm_01054	Mycsm_00182	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.985
AGB21479.1	AGB22593.1	Mycsm_01054	Mycsm_02242	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.	0.985
AGB21479.1	AGB22594.1	Mycsm_01054	Mycsm_02243	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.	0.993
AGB21479.1	AGB23335.1	Mycsm_01054	Mycsm_03013	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.980
AGB21479.1	AGB23560.1	Mycsm_01054	Mycsm_03253	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.802
AGB21479.1	AGB23695.1	Mycsm_01054	Mycsm_03395	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Threonine dehydratase; PFAM: Pyridoxal-phosphate dependent enzyme.	0.933
AGB21479.1	AGB24605.1	Mycsm_01054	Mycsm_04360	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.849
AGB21479.1	AGB25563.1	Mycsm_01054	Mycsm_05372	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.984
AGB21479.1	ilvC	Mycsm_01054	Mycsm_02244	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.997
AGB21479.1	leuB	Mycsm_01054	Mycsm_02248	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	Isocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.	0.981

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