upp protein (Spiroplasma citri) - STRING interaction network

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upp

Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)

Predicted Functional Partners:

pyrH

0.947

deoA

0.937

ywlF

0.916

proS

0.668

tyrS

0.619

guaA

0.608

cmk

0.596

glyA

0.581

tdk

0.579

APE74058.1

0.559

Your Current Organism:

Spiroplasma citri

NCBI taxonomy Id: 2133
Other names: ATCC 27556, NCPPB 2647, S. citri

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APE74058.1	upp	SCITRI_00144	SCITRI_00145	Hypothetical protein.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.559
cmk	guaA	SCITRI_00424	SCITRI_00386	Cytidylate kinase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.601
cmk	pyrH	SCITRI_00424	SCITRI_00478	Cytidylate kinase.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.487
cmk	upp	SCITRI_00424	SCITRI_00145	Cytidylate kinase.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.596
deoA	guaA	SCITRI_00529	SCITRI_00386	Pyrimidine-nucleoside phosphorylase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.582
deoA	tdk	SCITRI_00529	SCITRI_0056	Pyrimidine-nucleoside phosphorylase.	Thymidine kinase.	0.962
deoA	upp	SCITRI_00529	SCITRI_00145	Pyrimidine-nucleoside phosphorylase.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.937
glyA	guaA	SCITRI_001840	SCITRI_00386	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.700
glyA	pyrH	SCITRI_001840	SCITRI_00478	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.410
glyA	tdk	SCITRI_001840	SCITRI_0056	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Thymidine kinase.	0.496
glyA	upp	SCITRI_001840	SCITRI_00145	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.581
glyA	ywlF	SCITRI_001840	SCITRI_00206	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Ribose 5-phosphate isomerase.	0.932
guaA	cmk	SCITRI_00386	SCITRI_00424	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Cytidylate kinase.	0.601
guaA	deoA	SCITRI_00386	SCITRI_00529	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Pyrimidine-nucleoside phosphorylase.	0.582
guaA	glyA	SCITRI_00386	SCITRI_001840	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.700
guaA	proS	SCITRI_00386	SCITRI_001775	GMP synthase; Catalyzes the synthesis of GMP from XMP.	prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).	0.691
guaA	pyrH	SCITRI_00386	SCITRI_00478	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.678
guaA	tdk	SCITRI_00386	SCITRI_0056	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Thymidine kinase.	0.424
guaA	upp	SCITRI_00386	SCITRI_00145	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.608
guaA	ywlF	SCITRI_00386	SCITRI_00206	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribose 5-phosphate isomerase.	0.468