| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | guaA | SCITRI_00786 | SCITRI_00386 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.795 |
| apt | guaC | SCITRI_00786 | SCITRI_00580 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.415 |
| apt | hprT | SCITRI_00786 | SCITRI_00385 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.536 |
| apt | hpt | SCITRI_00786 | SCITRI_001505 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.446 |
| apt | purA | SCITRI_00786 | SCITRI_00274 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.764 |
| apt | purB | SCITRI_00786 | SCITRI_00275 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase. | 0.975 |
| asnA | purA | SCITRI_0018 | SCITRI_00274 | Asparagine synthetase AsnA. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.903 |
| guaA | apt | SCITRI_00386 | SCITRI_00786 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.795 |
| guaA | guaC | SCITRI_00386 | SCITRI_00580 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.999 |
| guaA | hprT | SCITRI_00386 | SCITRI_00385 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.991 |
| guaA | hpt | SCITRI_00386 | SCITRI_001505 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.952 |
| guaA | pth | SCITRI_00386 | SCITRI_00276 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.648 |
| guaA | purA | SCITRI_00386 | SCITRI_00274 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.777 |
| guaA | purB | SCITRI_00386 | SCITRI_00275 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase. | 0.792 |
| guaA | pyrG | SCITRI_00386 | SCITRI_00273 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.881 |
| guaA | rdgB | SCITRI_00386 | SCITRI_00584 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.944 |
| guaC | apt | SCITRI_00580 | SCITRI_00786 | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.415 |
| guaC | guaA | SCITRI_00580 | SCITRI_00386 | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaC | hprT | SCITRI_00580 | SCITRI_00385 | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.912 |
| guaC | hpt | SCITRI_00580 | SCITRI_001505 | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | Putative hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.912 |
