rtcA protein (Methanosarcina mazei) - STRING interaction network

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rtcA

RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (352 aa)

Predicted Functional Partners:

rps4

0.963

rps6e

0.947

rps11

0.945

csl4

0.943

rrp42

0.932

AKB66272.1

0.931

rrp4

0.926

rtcB

0.920

AKB65865.1

0.917

AKB65281.1

0.901

Your Current Organism:

Methanosarcina mazei

NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB65281.1	AKB65865.1	MSMAS_2085	MSMAS_2669	Ribonuclease PH.	Putative RNA-processing protein.	0.903
AKB65281.1	AKB66272.1	MSMAS_2085	MSMAS_3076	Ribonuclease PH.	rRNA biogenesis protein Nop5/Nop56.	0.869
AKB65281.1	csl4	MSMAS_2085	MSMAS_2808	Ribonuclease PH.	Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.	0.996
AKB65281.1	rps11	MSMAS_2085	MSMAS_2527	Ribonuclease PH.	SSU ribosomal protein S14e (S11p); Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.	0.933
AKB65281.1	rps4	MSMAS_2085	MSMAS_2528	Ribonuclease PH.	SSU ribosomal protein S9e (S4p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.950
AKB65281.1	rps6e	MSMAS_2085	MSMAS_2239	Ribonuclease PH.	SSU ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.	0.929
AKB65281.1	rrp4	MSMAS_2085	MSMAS_2086	Ribonuclease PH.	Putative exosome complex RNA-binding protein 1; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.	0.999
AKB65281.1	rrp42	MSMAS_2085	MSMAS_2084	Ribonuclease PH.	Putative exosome complex exonuclease 2; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.	0.999
AKB65281.1	rtcA	MSMAS_2085	MSMAS_0017	Ribonuclease PH.	RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.	0.901
AKB65865.1	AKB65281.1	MSMAS_2669	MSMAS_2085	Putative RNA-processing protein.	Ribonuclease PH.	0.903
AKB65865.1	AKB66272.1	MSMAS_2669	MSMAS_3076	Putative RNA-processing protein.	rRNA biogenesis protein Nop5/Nop56.	0.965
AKB65865.1	csl4	MSMAS_2669	MSMAS_2808	Putative RNA-processing protein.	Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.	0.949
AKB65865.1	rps11	MSMAS_2669	MSMAS_2527	Putative RNA-processing protein.	SSU ribosomal protein S14e (S11p); Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.	0.956
AKB65865.1	rps4	MSMAS_2669	MSMAS_2528	Putative RNA-processing protein.	SSU ribosomal protein S9e (S4p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.974
AKB65865.1	rps6e	MSMAS_2669	MSMAS_2239	Putative RNA-processing protein.	SSU ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.	0.981
AKB65865.1	rrp4	MSMAS_2669	MSMAS_2086	Putative RNA-processing protein.	Putative exosome complex RNA-binding protein 1; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.	0.949
AKB65865.1	rrp42	MSMAS_2669	MSMAS_2084	Putative RNA-processing protein.	Putative exosome complex exonuclease 2; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.	0.940
AKB65865.1	rtcA	MSMAS_2669	MSMAS_0017	Putative RNA-processing protein.	RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.	0.917
AKB66272.1	AKB65281.1	MSMAS_3076	MSMAS_2085	rRNA biogenesis protein Nop5/Nop56.	Ribonuclease PH.	0.869
AKB66272.1	AKB65865.1	MSMAS_3076	MSMAS_2669	rRNA biogenesis protein Nop5/Nop56.	Putative RNA-processing protein.	0.965

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