STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtcARNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (352 aa)    
Predicted Functional Partners:
rps6e
SSU ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 0.981
rps4
SSU ribosomal protein S9e (S4p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 0.981
rps11
SSU ribosomal protein S14e (S11p); Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
    
 0.975
AKB66272.1
rRNA biogenesis protein Nop5/Nop56.
 
 
 0.973
csl4
Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
  
 0.972
rrp42
Putative exosome complex exonuclease 2; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
  
  0.962
rrp4
Putative exosome complex RNA-binding protein 1; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
  
  0.959
AKB65865.1
Putative RNA-processing protein.
   
 
 0.959
AKB65281.1
Ribonuclease PH.
  
 0.957
rps3ae
SSU ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family.
  
 
  0.950
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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