STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKB63269.1Methyl coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (570 aa)    
Predicted Functional Partners:
AKB63265.1
Methyl coenzyme M reductase beta subunit.
 
 0.999
AKB63266.1
Methyl coenzyme M reductase operon protein D.
 
 
 0.999
AKB63267.1
Methyl coenzyme M reductase operon protein C.
 
 
 0.999
AKB63268.1
Methyl coenzyme M reductase gamma subunit.
 
 0.999
AKB63590.1
Methyl coenzyme M reductase system component A2.
 
  
 0.978
AKB63556.1
Putative ABC transporter ATP-binding protein.
 
  
 0.964
AKB63264.1
Methyl coenzyme M reductase associated protein / Fe-S oxidoreductase, related to NifB/MoaA family.
 
 
 
 0.923
AKB66034.1
CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D.
 
  
 0.921
mtrA
N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
 
 
 0.920
mtrG
N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
 
 
 0.910
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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