STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mptAGTP cyclohydrolase I type 2; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (318 aa)    
Predicted Functional Partners:
moaA
Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
  0.901
AKB63758.1
Queuosine biosynthesis QueD, PTPS-I.
 
  
 0.845
AKB63798.1
Pyruvate kinase; Belongs to the pyruvate kinase family.
 
  
  0.843
AKB66491.1
Ribonucleotide reductase of class III (anaerobic), large subunit.
  
  
  0.832
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
  0.803
AKB63633.1
Adenylate cyclase.
    
  0.802
AKB63581.1
GDP-mannose mannosyl hydrolase.
    
  0.704
AKB63425.1
Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family.
  
  
 0.652
AKB66244.1
Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family.
  
  
 0.652
mptD
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
 
   
 0.645
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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