tmk protein (Methanosarcina mazei) - STRING interaction network

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tmk

Thymidylate kinase. (206 aa)

Predicted Functional Partners:

thyA

0.995

ndk

0.994

AKB65092.1

0.974

AKB66436.1

0.969

dut

0.961

surE

0.932

AKB65970.1

0.913

AKB64259.1

0.908

AKB63389.1

0.875

AKB65940.1

0.841

Your Current Organism:

Methanosarcina mazei

NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB63389.1	dut	MSMAS_0193	MSMAS_3043	Thymidylate synthase.	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.619
AKB63389.1	tmk	MSMAS_0193	MSMAS_0192	Thymidylate synthase.	Thymidylate kinase.	0.875
AKB64259.1	dut	MSMAS_1063	MSMAS_3043	Thymidylate synthase.	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.931
AKB64259.1	tmk	MSMAS_1063	MSMAS_0192	Thymidylate synthase.	Thymidylate kinase.	0.908
AKB65092.1	dut	MSMAS_1896	MSMAS_3043	Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.490
AKB65092.1	ndk	MSMAS_1896	MSMAS_2237	Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.990
AKB65092.1	thyA	MSMAS_1896	MSMAS_0076	Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.	0.908
AKB65092.1	tmk	MSMAS_1896	MSMAS_0192	Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Thymidylate kinase.	0.974
AKB65940.1	dut	MSMAS_2744	MSMAS_3043	Hypothetical protein.	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.818
AKB65940.1	thyA	MSMAS_2744	MSMAS_0076	Hypothetical protein.	Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.	0.468
AKB65940.1	tmk	MSMAS_2744	MSMAS_0192	Hypothetical protein.	Thymidylate kinase.	0.841
AKB65970.1	ndk	MSMAS_2774	MSMAS_2237	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.922
AKB65970.1	surE	MSMAS_2774	MSMAS_3272	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.913
AKB65970.1	thyA	MSMAS_2774	MSMAS_0076	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.	0.931
AKB65970.1	tmk	MSMAS_2774	MSMAS_0192	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Thymidylate kinase.	0.913
AKB66436.1	dut	MSMAS_3240	MSMAS_3043	dCMP deaminase.	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.926
AKB66436.1	surE	MSMAS_3240	MSMAS_3272	dCMP deaminase.	5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.901
AKB66436.1	thyA	MSMAS_3240	MSMAS_0076	dCMP deaminase.	Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.	0.977
AKB66436.1	tmk	MSMAS_3240	MSMAS_0192	dCMP deaminase.	Thymidylate kinase.	0.969
dut	AKB63389.1	MSMAS_3043	MSMAS_0193	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate synthase.	0.619