AKB63415.1 protein (Methanosarcina mazei) - STRING interaction network

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Score

AKB63415.1

GTP-binding and nucleic acid-binding protein YchF. (392 aa)

Predicted Functional Partners:

argS

0.852

infB

0.805

eif5a

0.780

fusA

0.777

rps7

0.775

rpl2

0.773

dnaG

0.762

leuS

0.760

rpl13

0.755

pheT

0.741

Your Current Organism:

Methanosarcina mazei

NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB63415.1	argS	MSMAS_0219	MSMAS_3315	GTP-binding and nucleic acid-binding protein YchF.	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.852
AKB63415.1	dnaG	MSMAS_0219	MSMAS_0020	GTP-binding and nucleic acid-binding protein YchF.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.	0.762
AKB63415.1	eif5a	MSMAS_0219	MSMAS_0383	GTP-binding and nucleic acid-binding protein YchF.	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	0.780
AKB63415.1	fusA	MSMAS_0219	MSMAS_2430	GTP-binding and nucleic acid-binding protein YchF.	Translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	0.777
AKB63415.1	infB	MSMAS_0219	MSMAS_2238	GTP-binding and nucleic acid-binding protein YchF.	Translation initiation factor 2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.805
AKB63415.1	leuS	MSMAS_0219	MSMAS_1017	GTP-binding and nucleic acid-binding protein YchF.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.760
AKB63415.1	pheT	MSMAS_0219	MSMAS_1915	GTP-binding and nucleic acid-binding protein YchF.	Phenylalanyl-tRNA synthetase beta chain.	0.741
AKB63415.1	rpl13	MSMAS_0219	MSMAS_2922	GTP-binding and nucleic acid-binding protein YchF.	LSU ribosomal protein L13Ae (L13p); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.755
AKB63415.1	rpl2	MSMAS_0219	MSMAS_2557	GTP-binding and nucleic acid-binding protein YchF.	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.773
AKB63415.1	rps7	MSMAS_0219	MSMAS_2429	GTP-binding and nucleic acid-binding protein YchF.	SSU ribosomal protein S5e (S7p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family.	0.775
argS	AKB63415.1	MSMAS_3315	MSMAS_0219	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	GTP-binding and nucleic acid-binding protein YchF.	0.852
argS	dnaG	MSMAS_3315	MSMAS_0020	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.	0.590
argS	eif5a	MSMAS_3315	MSMAS_0383	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	0.616
argS	fusA	MSMAS_3315	MSMAS_2430	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]	0.773
argS	infB	MSMAS_3315	MSMAS_2238	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Translation initiation factor 2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.817
argS	leuS	MSMAS_3315	MSMAS_1017	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.981
argS	pheT	MSMAS_3315	MSMAS_1915	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Phenylalanyl-tRNA synthetase beta chain.	0.818
argS	rpl13	MSMAS_3315	MSMAS_2922	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	LSU ribosomal protein L13Ae (L13p); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.827
argS	rpl2	MSMAS_3315	MSMAS_2557	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.848
argS	rps7	MSMAS_3315	MSMAS_2429	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	SSU ribosomal protein S5e (S7p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family.	0.857