STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panProteasome-activating AAA-ATPase (PAN), archaeal; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pr [...] (431 aa)    
Predicted Functional Partners:
AKB65271.1
Mov34 family protein.
  
 0.955
psmA
Proteasome subunit alpha, archaeal; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.935
psmB
Proteasome subunit beta, archaeal; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.909
AKB63702.1
Proteasome-activating AAA-ATPase (PAN), archaeal; Belongs to the AAA ATPase family.
  
  
 
0.905
rpl40e
LSU ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.872
AKB64479.1
Putative ankyrin repeat protein.
 
 
 0.809
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.790
AKB63491.1
Transcription factor.
 
 
 0.751
rpl2
LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
 
 
 0.746
pgk
Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
  
 0.722
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.