STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKB63497.1Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (202 aa)    
Predicted Functional Partners:
AKB63498.1
Cobalt-precorrin-4 C11-methyltransferase.
 
 0.999
AKB63501.1
Cobalt-precorrin-3b C17-methyltransferase.
 
 
 0.994
AKB63502.1
Cobalt-precorrin-8x methylmutase.
 
 
 0.994
cbiT
Cobalt-precorrin-6y C15-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
 
 
 0.990
cbiX
Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
 
  
 0.988
AKB63499.1
Cobalamin biosynthesis protein CbiG.
 
 
 0.985
AKB66135.1
Siroheme synthase; Precorrin-2 oxidase; Sirohydrochlorin ferrochelatase.
    
 0.983
AKB64189.1
Uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family.
 
 0.982
AKB63500.1
Cobalamin biosynthesis protein CbiG.
 
 
 0.979
cbiD
Cobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
 
 0.974
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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