Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AKB64401.1ATP-dependent protease La Type I; Belongs to the peptidase S16 family. (689 aa)    
Predicted Functional Partners:
AKB64402.1
TldD protein, part of TldE/TldD proteolytic complex.
     
 0.947
AKB64403.1
TldE protein, part of TldE/TldD proteolytic complex.
  
  
 0.945
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
 
  
 0.795
dnaK
Chaperone protein DnaK; Acts as a chaperone.
 
 0.771
AKB66478.1
Chaperone protein.
 
 0.768
rpl40e
LSU ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
  
  0.760
AKB65912.1
Malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.748
AKB63401.1
Heat shock protein 60 family chaperone GroEL; Thermosome subunit; Belongs to the TCP-1 chaperonin family.
 
 
 0.725
AKB66479.1
Heat shock protein 60 family chaperone GroEL; Thermosome subunit; Belongs to the TCP-1 chaperonin family.
 
 
 0.724
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 
 0.712
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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