STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (396 aa)    
Predicted Functional Partners:
AKB64417.1
Scaffold protein.
 
 0.998
AKB65924.1
Scaffold protein.
 
 0.992
AKB66331.1
Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2.
   
 0.990
thiI
tRNA S(4)U 4-thiouridine synthase (former ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
 0.988
AKB65923.1
Homocysteine desulfhydrase.
  
  
 
0.978
AKB65921.1
Hypothetical protein.
   
 0.905
AKB66347.1
Cysteine desulfurase.
  
 
 0.863
AKB65827.1
Iron-sulfur cluster assembly ATPase protein SufC.
  
 
 0.838
fdhD
Formate dehydrogenase chain D; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family.
  
 0.822
AKB65861.1
Putative iron binding protein from the HesB_IscA_SufA family.
 
 
 0.777
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.