STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKB65078.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (570 aa)    
Predicted Functional Partners:
AKB63840.1
Acetolactate synthase small subunit.
 
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.995
AKB63866.1
Alpha-acetolactate decarboxylase.
 
 
 0.987
AKB66375.1
3-isopropylmalate dehydrogenase.
 
 0.969
AKB64080.1
2-oxoglutarate oxidoreductase, beta subunit.
  
 
 0.968
AKB64079.1
2-oxoglutarate oxidoreductase, alpha subunit.
  
 
 0.966
AKB66520.1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.964
cimA
(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.960
AKB66519.1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.951
AKB66517.1
Pyruvate:ferredoxin oxidoreductase, gamma subunit.
  
 
 0.950
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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