Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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gene co-occurrence
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AKB65536.1Hypothetical protein; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71. (223 aa)    
Predicted Functional Partners:
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
 
 0.971
AKB65118.1
Asparagine synthetase (glutamine-hydrolyzing).
     0.827
fusA
Translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]
 
 
 0.822
nadK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
    
 0.708
AKB66006.1
Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
   
 0.696
AKB65539.1
Hypothetical protein.
 
  
  0.692
AKB65538.1
Hypothetical protein; Belongs to the UPF0212 family.
       0.640
AKB65537.1
Cytidine kinase; Belongs to the carbohydrate kinase PfkB family.
     
 0.578
rpl4
LSU ribosomal protein L1e (L4p); Forms part of the polypeptide exit tunnel.
 
     0.528
AKB66488.1
Inositol-1-phosphate synthase.
       0.518
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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