Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKB65537.1Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. (299 aa)    
Predicted Functional Partners:
AKB64439.1
AMP phosphohydrolase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
    
 0.979
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.972
AKB66259.1
Ribose-1,5-bisphosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
 
 0.939
AKB63902.1
Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 
 0.933
cmk
Cytidylate kinase.
 
 
 0.928
AKB63603.1
IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.927
guaAB
GMP synthase (glutamine-hydrolyzing), ATP pyrophosphatase subunit; Catalyzes the synthesis of GMP from XMP.
  
 
 0.922
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
  
  
 0.911
AKB65970.1
Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
    
  0.910
guaAA
GMP synthase (glutamine-hydrolyzing), amidotransferase subunit; Catalyzes the synthesis of GMP from XMP.
  
 
 0.907
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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