STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dphBDiphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (266 aa)    
Predicted Functional Partners:
fusA
Translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]
  
 
 0.994
AKB66006.1
Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
 0.934
AKB65536.1
Hypothetical protein; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71.
 
 
 0.932
guaAB
GMP synthase (glutamine-hydrolyzing), ATP pyrophosphatase subunit; Catalyzes the synthesis of GMP from XMP.
   
  
 0.867
AKB65118.1
Asparagine synthetase (glutamine-hydrolyzing).
  
 
  0.763
AKB65109.1
Hypothetical protein; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71.
 
 
 0.738
AKB65110.1
Hypothetical protein; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71.
 
 
 0.733
AKB63448.1
GTP-binding protein RBG1/RBG2.
  
    0.711
AKB65539.1
Hypothetical protein.
 
     0.698
AKB65902.1
Histone acetyltransferase, ELP3 family.
  
  
 0.693
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.