STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKB65578.1[NiFe] hydrogenase metallocenter assembly protein HypE. (348 aa)    
Predicted Functional Partners:
AKB65581.1
[NiFe] hydrogenase metallocenter assembly protein HypD.
 
 0.998
AKB63721.1
[NiFe] hydrogenase metallocenter assembly protein HypF.
 
 0.990
AKB65582.1
[NiFe] hydrogenase metallocenter assembly protein HypC.
 
 
 0.975
AKB65717.1
[NiFe] hydrogenase metallocenter assembly protein HypC.
 
 
 0.948
AKB65579.1
[NiFe] hydrogenase nickel incorporation-associated protein HypB.
 
  
 0.898
hypA
[NiFe] hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.885
purL
Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...]
    
0.770
AKB65584.1
Methanophenazine hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.766
AKB65715.1
Methanophenazine hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.766
AKB65709.1
Methanophenazine hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.763
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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