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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKB65609.1Phosphopantothenate synthetase, archaeal. (253 aa)    
Predicted Functional Partners:
AKB65608.1
Pantoate kinase, archaeal.
 
  
 0.998
AKB65607.1
Phosphopantothenoylcysteine synthetase.
 
  
 0.978
mfnA
L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.
    
 0.918
AKB64477.1
4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
AKB65610.1
Metal-dependent phosphohydrolase.
       0.865
dadD
S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...]
       0.832
AKB63198.1
Dephospho-CoA kinase archaeal, predicted; Belongs to the UPF0200 family.
 
     0.722
AKB63820.1
NMD protein affecting ribosome stability and mRNA decay.
 
     0.668
AKB65613.1
Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family.
       0.658
AKB63199.1
DUF54 conserved in archaea; Belongs to the UPF0201 family.
 
   
 0.657
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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