| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKB64218.1 | dadD | MSMAS_1022 | MSMAS_2416 | DNA-cytosine methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...] | 0.909 |
| AKB64935.1 | AKB65516.1 | MSMAS_1739 | MSMAS_2320 | Phosphorylase. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.804 |
| AKB64935.1 | dadD | MSMAS_1739 | MSMAS_2416 | Phosphorylase. | S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...] | 0.731 |
| AKB64999.1 | dadD | MSMAS_1803 | MSMAS_2416 | N-methylhydantoinase A/acetone carboxylase, beta subunit. | S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...] | 0.565 |
| AKB65516.1 | AKB64935.1 | MSMAS_2320 | MSMAS_1739 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Phosphorylase. | 0.804 |
| AKB65516.1 | AKB65613.1 | MSMAS_2320 | MSMAS_2417 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.633 |
| AKB65516.1 | dadD | MSMAS_2320 | MSMAS_2416 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...] | 0.994 |
| AKB65607.1 | AKB65608.1 | MSMAS_2411 | MSMAS_2412 | Phosphopantothenoylcysteine synthetase. | Pantoate kinase, archaeal. | 0.972 |
| AKB65607.1 | AKB65609.1 | MSMAS_2411 | MSMAS_2413 | Phosphopantothenoylcysteine synthetase. | Phosphopantothenate synthetase, archaeal. | 0.978 |
| AKB65607.1 | AKB65610.1 | MSMAS_2411 | MSMAS_2414 | Phosphopantothenoylcysteine synthetase. | Metal-dependent phosphohydrolase. | 0.534 |
| AKB65607.1 | AKB65613.1 | MSMAS_2411 | MSMAS_2417 | Phosphopantothenoylcysteine synthetase. | Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.503 |
| AKB65607.1 | dadD | MSMAS_2411 | MSMAS_2416 | Phosphopantothenoylcysteine synthetase. | S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...] | 0.595 |
| AKB65608.1 | AKB65607.1 | MSMAS_2412 | MSMAS_2411 | Pantoate kinase, archaeal. | Phosphopantothenoylcysteine synthetase. | 0.972 |
| AKB65608.1 | AKB65609.1 | MSMAS_2412 | MSMAS_2413 | Pantoate kinase, archaeal. | Phosphopantothenate synthetase, archaeal. | 0.998 |
| AKB65608.1 | AKB65610.1 | MSMAS_2412 | MSMAS_2414 | Pantoate kinase, archaeal. | Metal-dependent phosphohydrolase. | 0.607 |
| AKB65608.1 | dadD | MSMAS_2412 | MSMAS_2416 | Pantoate kinase, archaeal. | S-adenosylhomocysteine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon th [...] | 0.570 |
| AKB65609.1 | AKB65607.1 | MSMAS_2413 | MSMAS_2411 | Phosphopantothenate synthetase, archaeal. | Phosphopantothenoylcysteine synthetase. | 0.978 |
| AKB65609.1 | AKB65608.1 | MSMAS_2413 | MSMAS_2412 | Phosphopantothenate synthetase, archaeal. | Pantoate kinase, archaeal. | 0.998 |
| AKB65609.1 | AKB65610.1 | MSMAS_2413 | MSMAS_2414 | Phosphopantothenate synthetase, archaeal. | Metal-dependent phosphohydrolase. | 0.865 |
| AKB65609.1 | AKB65613.1 | MSMAS_2413 | MSMAS_2417 | Phosphopantothenate synthetase, archaeal. | Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.658 |
