Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AKB66034.1CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D. (409 aa)    
Predicted Functional Partners:
AKB66035.1
CoB--CoM heterodisulfide reductase 2 subunit E.
 
  
 0.999
AKB64109.1
CoB--CoM heterodisulfide reductase subunit B.
 
 
 0.969
AKB63516.1
CoB--CoM heterodisulfide reductase subunit C.
 
 
 0.957
AKB64110.1
CoB--CoM heterodisulfide reductase subunit C.
 
 
 0.956
AKB64111.1
CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
  
 0.949
AKB64468.1
CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
  
 0.944
AKB63515.1
CoB--CoM heterodisulfide reductase subunit B.
 
 
0.943
AKB63269.1
Methyl coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
 
  
 0.920
AKB63267.1
Methyl coenzyme M reductase operon protein C.
 
  
  0.918
AKB63268.1
Methyl coenzyme M reductase gamma subunit.
 
  
  0.918
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.