pelA protein (Methanosarcina mazei) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pelA

Putative cell division protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (350 aa)

Predicted Functional Partners:

AKB66063.1

0.959

AKB64073.1

0.932

rpl2

0.863

tuf

0.849

rpl29

0.849

rps3ae

0.793

rpl19e

0.786

eif5a

0.771

rpl10

0.765

rps3

0.761

Your Current Organism:

Methanosarcina mazei

NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB64073.1	AKB66063.1	MSMAS_0877	MSMAS_2867	RNase L inhibitor.	Hypothetical protein.	0.718
AKB64073.1	pelA	MSMAS_0877	MSMAS_2866	RNase L inhibitor.	Putative cell division protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.	0.932
AKB64073.1	rpl10	MSMAS_0877	MSMAS_0287	RNase L inhibitor.	LSU ribosomal protein P0 (L10p); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	0.902
AKB64073.1	rpl19e	MSMAS_0877	MSMAS_2542	RNase L inhibitor.	LSU ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.	0.887
AKB64073.1	rpl2	MSMAS_0877	MSMAS_2557	RNase L inhibitor.	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.986
AKB64073.1	rpl29	MSMAS_0877	MSMAS_2553	RNase L inhibitor.	LSU ribosomal protein L35e (L29p); Belongs to the universal ribosomal protein uL29 family.	0.806
AKB64073.1	rps3	MSMAS_0877	MSMAS_2554	RNase L inhibitor.	SSU ribosomal protein S3e (S3p); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.	0.971
AKB64073.1	rps3ae	MSMAS_0877	MSMAS_1115	RNase L inhibitor.	SSU ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family.	0.982
AKB64073.1	tuf	MSMAS_0877	MSMAS_2431	RNase L inhibitor.	Translation elongation factor 1 alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.604
AKB66063.1	AKB64073.1	MSMAS_2867	MSMAS_0877	Hypothetical protein.	RNase L inhibitor.	0.718
AKB66063.1	pelA	MSMAS_2867	MSMAS_2866	Hypothetical protein.	Putative cell division protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.	0.959
AKB66063.1	rpl10	MSMAS_2867	MSMAS_0287	Hypothetical protein.	LSU ribosomal protein P0 (L10p); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	0.958
AKB66063.1	rpl19e	MSMAS_2867	MSMAS_2542	Hypothetical protein.	LSU ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.	0.951
AKB66063.1	rpl2	MSMAS_2867	MSMAS_2557	Hypothetical protein.	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.963
AKB66063.1	rpl29	MSMAS_2867	MSMAS_2553	Hypothetical protein.	LSU ribosomal protein L35e (L29p); Belongs to the universal ribosomal protein uL29 family.	0.951
eif5a	pelA	MSMAS_0383	MSMAS_2866	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	Putative cell division protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.	0.771
eif5a	rpl10	MSMAS_0383	MSMAS_0287	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	LSU ribosomal protein P0 (L10p); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	0.969
eif5a	rpl19e	MSMAS_0383	MSMAS_2542	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	LSU ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.	0.980
eif5a	rpl2	MSMAS_0383	MSMAS_2557	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.999
eif5a	rpl29	MSMAS_0383	MSMAS_2553	Eukaryotic translation initiation factor 5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.	LSU ribosomal protein L35e (L29p); Belongs to the universal ribosomal protein uL29 family.	0.981

page 1 of 5

Server load: medium (60%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About