STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
groSHeat shock protein 60 family co-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (92 aa)    
Predicted Functional Partners:
groL
Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.999
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
 
 
 0.994
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 
 0.990
AKB66478.1
Chaperone protein.
  
 
 0.965
AKB64453.1
Heat shock protein 60 family chaperone GroEL; Thermosome subunit; Belongs to the TCP-1 chaperonin family.
 
 
 0.940
AKB66479.1
Heat shock protein 60 family chaperone GroEL; Thermosome subunit; Belongs to the TCP-1 chaperonin family.
 
 
 0.934
AKB63401.1
Heat shock protein 60 family chaperone GroEL; Thermosome subunit; Belongs to the TCP-1 chaperonin family.
 
 
 0.933
AKB65475.1
Chaperone protein.
  
 
 0.919
AKB65093.1
Peptidyl-prolyl cis-trans isomerase.
  
 
 0.846
AKB65912.1
Malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 
 0.822
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.