node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB64128.1 | hisA | MSMAS_0932 | MSMAS_3164 | Prephenate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.615 |
AKB64128.1 | hisC | MSMAS_0932 | MSMAS_3258 | Prephenate dehydratase. | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. | 0.987 |
AKB64128.1 | hisF | MSMAS_0932 | MSMAS_2970 | Prephenate dehydratase. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.462 |
AKB64128.1 | hisH | MSMAS_0932 | MSMAS_2654 | Prephenate dehydratase. | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.414 |
cobQ | hisC | MSMAS_1237 | MSMAS_3258 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. | 0.964 |
hisA | AKB64128.1 | MSMAS_3164 | MSMAS_0932 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Prephenate dehydratase. | 0.615 |
hisA | hisB | MSMAS_3164 | MSMAS_3163 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.999 |
hisA | hisC | MSMAS_3164 | MSMAS_3258 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. | 0.988 |
hisA | hisD | MSMAS_3164 | MSMAS_0879 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisE | MSMAS_3164 | MSMAS_2327 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-ATP pyrophosphatase. | 0.997 |
hisA | hisF | MSMAS_3164 | MSMAS_2970 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | MSMAS_3164 | MSMAS_3165 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
hisA | hisH | MSMAS_3164 | MSMAS_2654 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | MSMAS_3164 | MSMAS_2662 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | MSMAS_3163 | MSMAS_3164 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.999 |
hisB | hisC | MSMAS_3163 | MSMAS_3258 | Imidazoleglycerol-phosphate dehydratase. | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. | 0.999 |
hisB | hisD | MSMAS_3163 | MSMAS_0879 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | MSMAS_3163 | MSMAS_2327 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosyl-ATP pyrophosphatase. | 0.997 |
hisB | hisF | MSMAS_3163 | MSMAS_2970 | Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | MSMAS_3163 | MSMAS_3165 | Imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.997 |