STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
cbiA-2Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (439 aa)    
Predicted Functional Partners:
AKB63502.1
Cobalt-precorrin-8x methylmutase.
 
 0.996
AKB65878.1
CobN component of cobalt chelatase involved in B12 biosynthesis.
 
 
 0.984
AKB66263.1
CobN-like chelatase BtuS for metalloporphyrine salvage.
 
 
 0.984
AKB63501.1
Cobalt-precorrin-3b C17-methyltransferase.
 
 
 0.981
AKB66264.1
CobN-like chelatase BtuS for metalloporphyrine salvage.
 
 
 0.975
AKB64741.1
Cob(I)alamin adenosyltransferase.
 
 
 0.951
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.949
cbiD
Cobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.944
AKB63499.1
Cobalamin biosynthesis protein CbiG.
 
  
 0.931
AKB63500.1
Cobalamin biosynthesis protein CbiG.
 
  
 0.890
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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