Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AKB66472.1ATP-dependent RNA helicase, EIF-4A family. (852 aa)    
Predicted Functional Partners:
rpl1
LSU ribosomal protein L10Ae (L1p); Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.895
pcn
DNA polymerase sliding clamp protein PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 
 
 0.885
AKB63291.1
ATP-dependent DNA helicase RecQ.
   
 
 0.873
AKB63211.1
Replication factor A (ssDNA-binding protein).
 
 
 0.854
smc
Chromosome partition protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family.
 
 
 0.845
AKB66471.1
Glycyl-tRNA synthetase.
       0.827
rpl40e
LSU ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 
  0.818
AKB64203.1
Replication protein A (two OB fold, one zinc finger).
 
 
 0.815
AKB66124.1
Replication factor-A protein 1.
 
 
 0.805
AKB65872.1
Archaeal DNA polymerase I.
 
 
 
 0.801
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.