STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutS2DNA mismatch repair protein; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (707 aa)    
Predicted Functional Partners:
rpl2
LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
   0.999
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
 
 
 0.948
rpl29
LSU ribosomal protein L35e (L29p); Belongs to the universal ribosomal protein uL29 family.
 
 
   0.788
rpl15
LSU ribosomal protein L27Ae (L15p); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
 
   0.740
rps3
SSU ribosomal protein S3e (S3p); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.
 
 
   0.729
rps17
SSU ribosomal protein S11e (S17p); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
 
 
   0.726
rpl10e
LSU ribosomal protein L10e (L16p); Belongs to the universal ribosomal protein uL16 family.
 
 
   0.721
rps4
SSU ribosomal protein S9e (S4p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
   0.718
rps15
SSU ribosomal protein S13e (S15p).
   
   0.707
rpl6
LSU ribosomal protein L9e (L6p); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
 
 0.697
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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