STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHE27864.1Alkaline phosphatase; Belongs to the alkaline phosphatase family. (575 aa)    
Predicted Functional Partners:
secA
Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.
    
 
 0.917
folE
GTP cyclohydrolase I.
   
 
  0.916
secB
Preprotein translocase subunit SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
    
 
 0.900
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
    
 
 0.899
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.859
SHF22546.1
Hypothetical protein.
  
 0.839
SHE66315.1
AAA domain-containing protein.
   
 
 0.678
SHF04960.1
AAA domain-containing protein.
   
 
 0.678
SHE30079.1
Mutator mutT protein; Belongs to the Nudix hydrolase family.
    
 0.675
SHE39793.1
Phosphate transport system substrate-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family.
  
  
 0.611
Your Current Organism:
Thermomonas hydrothermalis
NCBI taxonomy Id: 213588
Other names: ATCC BAA-470, DSM 14834, T. hydrothermalis, Thermomonas hydrothermalis Alves et al. 2003, strain SGM-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.