node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHE38801.1 | alaS | SAMN02745204_00327 | SAMN02745204_00329 | Transposase, IS605 OrfB family, central region. | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | 0.491 |
SHE38801.1 | recX | SAMN02745204_00327 | SAMN02745204_00328 | Transposase, IS605 OrfB family, central region. | Regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.768 |
SHE68596.1 | radA | SAMN02745204_00941 | SAMN02745204_01641 | Competence protein ComEC. | DNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.427 |
SHE68596.1 | recA | SAMN02745204_00941 | SAMN02745204_00324 | Competence protein ComEC. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.629 |
SHE68596.1 | recX | SAMN02745204_00941 | SAMN02745204_00328 | Competence protein ComEC. | Regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.546 |
SHE68596.1 | ruvC | SAMN02745204_00941 | SAMN02745204_01145 | Competence protein ComEC. | Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.427 |
SHE99344.1 | lexA | SAMN02745204_01566 | SAMN02745204_00323 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.731 |
SHE99344.1 | polA | SAMN02745204_01566 | SAMN02745204_02107 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.493 |
SHE99344.1 | radA | SAMN02745204_01566 | SAMN02745204_01641 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | DNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.616 |
SHE99344.1 | recA | SAMN02745204_01566 | SAMN02745204_00324 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.794 |
SHE99344.1 | recX | SAMN02745204_01566 | SAMN02745204_00328 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.540 |
SHF18909.1 | lexA | SAMN02745204_01977 | SAMN02745204_00323 | ATP-dependent DNA helicase DinG. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.411 |
SHF18909.1 | polA | SAMN02745204_01977 | SAMN02745204_02107 | ATP-dependent DNA helicase DinG. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.981 |
SHF18909.1 | recA | SAMN02745204_01977 | SAMN02745204_00324 | ATP-dependent DNA helicase DinG. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.835 |
SHF18909.1 | recX | SAMN02745204_01977 | SAMN02745204_00328 | ATP-dependent DNA helicase DinG. | Regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.589 |
alaS | SHE38801.1 | SAMN02745204_00329 | SAMN02745204_00327 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | Transposase, IS605 OrfB family, central region. | 0.491 |
alaS | recA | SAMN02745204_00329 | SAMN02745204_00324 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.529 |
alaS | recX | SAMN02745204_00329 | SAMN02745204_00328 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. | Regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.558 |
lexA | SHE99344.1 | SAMN02745204_00323 | SAMN02745204_01566 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.731 |
lexA | SHF18909.1 | SAMN02745204_00323 | SAMN02745204_01977 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | ATP-dependent DNA helicase DinG. | 0.411 |