STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHE84421.1Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (365 aa)    
Predicted Functional Partners:
SHF13552.1
2-oxoisovalerate dehydrogenase E1 component.
 
 
 0.991
SHE68248.1
Glutamate synthase domain-containing protein 2; Belongs to the glutamate synthase family.
  
 0.973
SHE73881.1
Alanine-synthesizing transaminase.
   
 
 0.920
SHE75013.1
Branched-chain amino acid aminotransferase.
  
 
 0.897
SHE82044.1
Indolepyruvate ferredoxin oxidoreductase.
    
 0.893
SHE32095.1
L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
 
 0.889
SHE79900.1
Dihydrolipoamide dehydrogenase.
  
 
 0.870
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
 0.865
icmF
methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
 
  
 0.860
SHE61718.1
2,4-dienoyl-CoA reductase (NADPH2).
  
 0.821
Your Current Organism:
Thermomonas hydrothermalis
NCBI taxonomy Id: 213588
Other names: ATCC BAA-470, DSM 14834, T. hydrothermalis, Thermomonas hydrothermalis Alves et al. 2003, strain SGM-6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.