STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hprKHPr kinase/phosphorylase; Belongs to the HPrK/P family. (307 aa)    
Predicted Functional Partners:
rpe-2
Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.
     
 0.886
manA
Mannose-6-phosphate isomerase.
     
 0.880
glpF
Glycerol uptake facilitator protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
     
 0.879
tkt-2
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
      
 0.878
lgt-2
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
  
  
 0.793
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
     
 0.791
trxB
Thioredoxin reductase.
     
 0.779
mngA
PTS system 2-O-a-mannosyl-D-glycerate specific transporter IIABC component.
  
  
 0.755
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
     
 0.754
rpe
Ribulose-phosphate 3-epimerase.
     
 0.737
Your Current Organism:
Spiroplasma poulsonii
NCBI taxonomy Id: 2138
Other names: ATCC 43153, CIP 106072, Melanogaster sex ratio organism, S. poulsonii, Spiroplasma sp. DW-1, Spiroplasma sp. MSRO, strain DW-1
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