STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RUM_02730Hypothetical protein. (84 aa)    
Predicted Functional Partners:
recF
recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
  
    0.849
RUM_02760
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
    0.819
RUM_02750
Uncharacterized conserved protein.
  
    0.813
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
    0.770
RUM_02710
Hypothetical protein.
       0.755
RUM_08880
Hypothetical protein.
  
     0.641
RUM_04470
Hypothetical protein.
  
     0.624
RUM_19770
Hypothetical protein.
  
     0.593
RUM_03980
LysM domain.
  
     0.558
RUM_14600
Helix-turn-helix.
  
     0.555
Your Current Organism:
Ruminococcus champanellensis
NCBI taxonomy Id: 213810
Other names: R. champanellensis 18P13 = JCM 17042, Ruminococcus champanellensis 18P13, Ruminococcus champanellensis 18P13 = JCM 17042, Ruminococcus champanellensis DSM 18848, Ruminococcus champanellensis JCM 17042, Ruminococcus champanellensis JCM 17042 = 18P13, Ruminococcus sp. 18P13
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