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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RUM_14640LuxS protein involved in autoinducer AI2 synthesis; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (157 aa)    
Predicted Functional Partners:
RUM_16810
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
 
 
 0.983
RUM_22270
B12 binding domain./Pterin binding enzyme./Homocysteine S-methyltransferase.
    
 0.960
RUM_07270
O-acetylhomoserine sulfhydrolase.
     
 0.901
RUM_07500
O-acetylhomoserine sulfhydrolase.
     
 0.901
RUM_08320
Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.847
RUM_21220
Cysteine synthase.
  
 
 0.847
RUM_16570
Homoserine dehydrogenase.
     
 0.813
RUM_14650
Membrane proteins related to metalloendopeptidases.
  
  
 0.474
RUM_08410
Ribosomal RNA small subunit methyltransferase RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
     
 0.417
RUM_00700
Phosphopantetheine attachment site.
  
  
 0.416
Your Current Organism:
Ruminococcus champanellensis
NCBI taxonomy Id: 213810
Other names: R. champanellensis 18P13 = JCM 17042, Ruminococcus champanellensis 18P13, Ruminococcus champanellensis 18P13 = JCM 17042, Ruminococcus champanellensis DSM 18848, Ruminococcus champanellensis JCM 17042, Ruminococcus champanellensis JCM 17042 = 18P13, Ruminococcus sp. 18P13
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