Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
YPO0010Similar to several including: Streptomyces coelicolor putative GntR-famly transcriptional regulator scf37.08 TR:Q9RJZ3 (EMBL:AL133210) (246 aa) fasta scores: E(): 6.5e-18, 32.6% id in 215 aa and Escherichia coli hypothetical protein YieP SW:YIEP_ECOLI (P31475) (181 aa) fasta scores: E(): 0, 64.1% id in 181 aa. (229 aa)    
Predicted Functional Partners:
YPO1279
Putative transcriptional regulatory protein; Similar to Escherichia coli Uxu operon transcriptional regulator UxuR SW:UXUR_ECOLI (P39161) (257 aa) fasta scores: E(): 0, 52.9% id in 244 aa, and to Erwinia chrysanthemi Exu regulon transcriptional regulator ExuR SW:EXUR_ERWCH (Q9X9E0) (259 aa) fasta scores: E(): 0,44.9% id in 245 aa.
  
   
 0.817
b4390
Similar to Salmonella typhimurium transcriptional regulator NadR SW:NADR_SALTY (P24518) (409 aa) fasta scores: E(): 0, 85.0% id in 406 aa, and to Escherichia coli transcriptional regulator NadR SW:NADR_ECOLI (P27278) (410 aa) fasta scores: E(): 0, 83.7% id in 406 aa.
   
  
 0.688
YPO3651
Similar to Streptomyces coelicolor putative GntR-family transcriptional regulator SC9A4.30 TR:CAC01657 (EMBL:AL391072) (224 aa) fasta scores: E(): 8.8e-11, 31.8% id in 176 aa, and to Pseudomonas aeruginosa probable transcriptional regulator PA0797 TR:AAG04186 (EMBL:AE004515) (240 aa) fasta scores: E(): 1.1e-10, 29.6% id in 216 aa.
  
  
 0.643
YPO0009
Putative membrane transport protein; Similar to many proteins belonging to the major facilitator family of drug resistance translocases e.g. Neisseria gonorrhoeae efflux transporter membrane protein AgrA TR:BAB13740 (EMBL:AB032563) (468 aa) fasta scores: E(): 0, 45.4% id in 460 aa Also highly similar to Escherichia coli hypothetical 51.5 kDa protein in rbsr-rrsc intergenic region yieO SW:YIEO_ECOLI (P31474) (475 aa) fasta scores: E(): 0, 74.2% id in 457 aa.
       0.616
cra
Similar to Escherichia coli fructose repressor (catabolite repressor/activator) FruR SW:FRUR_ECOLI (P21168) (334 aa) fasta scores: E(): 0, 89.2% id in 334 aa,and to Vibrio cholerae fructose repressor VCA0519 TR:Q9KM69 (EMBL:AE004382) (326 aa) fasta scores: E(): 0, 45.5% id in 323 aa.
  
 
 
 0.523
YPO0736
Putative regulatory protein; N-terminus similar to the N-terminus regions of Photobacterium profundum protein required for pressure-responsive gene expression ToxR TR:O66013 (EMBL:U77060) (290 aa) fasta scores: E(): 1.6e-06, 30.0% id in 150 aa, and to Vibrio fischeri transmembrane transcriptional activator ToxR TR:Q56689 (EMBL:L29053) (316 aa) fasta scores: E(): 2.1e-06, 28.5% id in 172 aa.
      
 0.499
nanT
Putative sugar transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
  
   
 0.476
nfrC
UDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
   
  
 0.447
YPO1890
GntR-family putative transcriptional regulatory protein; Similar to Deinococcus radiodurans GntR-family transcriptional regulator DRA0211 TR:Q9RYU6 (EMBL:AE001863) (279 aa) fasta scores: E(): 8.7e-28, 40.1% id in 232 aa,and to Escherichia coli hypothetical transcriptional regulator YegW SW:YEGW_ECOLI (P76420) (248 aa) fasta scores: E(): 9.4e-18, 29.2% id in 226 aa.
  
  
 0.425
kdsD
Conserved hypothetical protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).
   
  
 0.422
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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