STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfa-2Similar to Escherichia coli lipopolysaccharide core biosynthesis heptosyltransferase-1 RfaC SW:RFAC_ECOLI (P24173) (319 aa) fasta scores: E(): 0, 68.3% id in 319 aa. (321 aa)    
Predicted Functional Partners:
rfaF
Similar to Escherichia coli ADP-heptose--LPS heptosyltransferase II RfaF, involved in LPS core biosynthesis, SW:RFAF_ECOLI (P37692) (348 aa) fasta scores: E(): 0, 73.8% id in 347 aa.
 
0.999
YPO0416
Similar to Escherichia coli lipopolysaccharide core biosynthesis protein RfaQ or WaaQ SW:RFAQ_ECOLI (P25742) (344 aa) fasta scores: E(): 2.3e-45, 40.356% id in 337 aa and to Salmonella typhimurium lipopolysaccharide core biosynthesis protein RfaQ or WaaQ TR:O68270 (EMBL:AF026386) (344 aa) fasta scores: E(): 3.8e-46, 41.246% id in 337 aa.
 
 
 0.986
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
 
 0.983
nuoD
NADH dehydrogenase I chain C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
 
 0.952
htrM
ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
 
  
 0.932
rfaE
ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
 
 
 0.903
fdx-2
Similar to Chromatium vinosum 2[4Fe-4S] ferredoxin Fdx SW:FER_CHRVI (P00208) (82 aa) fasta scores: E(): 5.8e-17, 60.5% id in 76 aa, and to Escherichia coli putative ferredoxin-like protein YfhL SW:YFHL_ECOLI (P52102) (86 aa) fasta scores: E(): 9.7e-30, 79.1% id in 86 aa.
  
   0.877
nuoM
NADH dehydrogenase I chain M; Similar to Escherichia coli SW:NUOM_ECOLI (P31978) (509 aa) fasta scores: E(): 0, 85.6% id in 513 aa, and to Pseudomonas aeruginosa NADH dehydrogenase I chain M NuoM TR:AAG06036 (EMBL:AE004693) (509 aa) fasta scores: E(): 0,74.9% id in 502 aa.
   
   0.752
nuoH
NADH dehydrogenase I chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
   
   0.751
nuoN
NADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family.
    
   0.748
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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