STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tusDConserved hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE. (131 aa)    
Predicted Functional Partners:
tusC
Conserved hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
 
 0.999
tusB
Conserved hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
 
 0.998
tusE
Putative sulfite reductase subunit protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD (By similarity).
 
 
 0.990
tusA
Conserved hypothetical protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
 
 
 0.988
YPO0196
Putative DNA-binding protein; Similar to Escherichia coli hypothetical protein YheO SW:YHEO_ECOLI (P45533) (240 aa) fasta scores: E(): 0,86.7% id in 240 aa, and to Vibrio cholerae hypothetical protein VC0355 vc0355 TR:Q9KV03 (EMBL:AE004124) (240 aa) fasta scores: E(): 0, 66.2% id in 234 aa.
  
    0.810
YPO0275
Conserved hypothetical protein; Similar to Escherichia coli and Salmonella typhimurium hypothetical protein YedF SW:YEDF_ECOLI (P31065) (77 aa) fasta scores: E(): 1.5e-26, 94.6% id in 74 aa. Note alternative possible translational start site at codon 17; Belongs to the sulfur carrier protein TusA family.
  
 
 0.781
rpsl
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
       0.523
YPO3001
Putative pyridine nucleotide-disulphide oxidoreductase; Similar to Staphylococcus aureus coenzyme A disulfide reductase TR:O52582 (EMBL:AF041467) (438 aa) fasta scores: E(): 0, 39.1% id in 445 aa, and to Vibrio cholerae NADH putative oxidase Vca0644 TR:Q9KLU7 (EMBL:AE004394) (567 aa) fasta scores: E(): 0, 49.1% id in 566 aa.
  
 
 0.506
sprT
Similar to Escherichia coli hypothetical protein SprT SW:SPRT_ECOLI (P39902) (165 aa) fasta scores: E(): 0,69.8% id in 162 aa, and to Haemophilus influenzae hypothetical protein HI1173 SW:SPRT_HAEIN (P44119) (156 aa) fasta scores: E(): 1.8e-30, 52.0% id in 148 aa.
  
    0.501
fkpA
Similar to Escherichia coli FkbP-type peptidyl-prolyl cis-trans isomerase SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 0, 76.0% id in 267 aa.
       0.465
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.