STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YPO0664Putative MutT-family protein; Similar to Rhodobacter sphaeroides tellurite resistance protein TrgA TR:O07841 (EMBL:AF004296) (361 aa) fasta scores: E(): 5.9e-21, 37.8% id in 196 aa, and to Escherichia coli hypothetical protein YqiE SW:YQIE_ECOLI (P36651) (209 aa) fasta scores: E(): 0, 82.7% id in 208 aa. (210 aa)    
Predicted Functional Partners:
YPO0144
Putative hydrolase; Similar to Escherichia coli ADP compounds hydrolase NudE SW:NUDE_ECOLI (P45799) (186 aa) fasta scores: E(): 0,74.7% id in 178 aa.
  
  
  0.927
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
 0.924
b4383
Thymidine phosphorylase (pseudogene); Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
    
  0.922
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.921
pgm
Phosphoglucomutase; Similar to Escherichia coli phosphoglucomutase Pgm SW:PGMU_ECOLI (P36938) (546 aa) fasta scores: E(): 0, 82.8% id in 546 aa, and to Vibrio cholerae phosphoglucomutase VC2095 TR:Q9KQA5 (EMBL:AE004283) (548 aa) fasta scores: E(): 0, 69.6% id in 546 aa.
   
 
  0.920
YPO0665
Similar to Escherichia coli hypothetical protein YqiB SW:YQIB_ECOLI (P36652) (140 aa) fasta scores: E(): 0,79.7% id in 138 aa, and to Vibrio cholerae hypothetical protein VC2434 TR:Q9KPD6 (EMBL:AE004313) (148 aa) fasta scores: E(): 1.6e-26, 49.3% id in 140 aa.
  
    0.860
bioR
Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
   
    0.758
rnr
Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily.
   
 0.720
icc
Icc protein homologue; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
 
 
 0.718
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
  
 
 0.676
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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