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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
YPO0664Putative MutT-family protein; Similar to Rhodobacter sphaeroides tellurite resistance protein TrgA TR:O07841 (EMBL:AF004296) (361 aa) fasta scores: E(): 5.9e-21, 37.8% id in 196 aa, and to Escherichia coli hypothetical protein YqiE SW:YQIE_ECOLI (P36651) (209 aa) fasta scores: E(): 0, 82.7% id in 208 aa. (210 aa)    
Predicted Functional Partners:
nudJ
Similar to Escherichia coli hypothetical protein YmfB SW:YMFB_ECOLI (P75965) (153 aa) fasta scores: E(): 0,75.0% id in 148 aa, to Pseudomonas hydrogenothermophila MutT-like protein TR:Q9WXC6 (EMBL:AB018741) (159 aa) fasta scores: E(): 3.4e-18, 43.1% id in 144 aa, and to Xylella fastidiosa phosphohydrolase XF1441 TR:Q9PDD8 (EMBL:AE003974) (152 aa) fasta scores: E(): 1.2e-16, 43.3% id in 141 aa; Belongs to the Nudix hydrolase family. NudJ subfamily.
   
 
 0.931
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
    
 0.915
YPO0665
Similar to Escherichia coli hypothetical protein YqiB SW:YQIB_ECOLI (P36652) (140 aa) fasta scores: E(): 0,79.7% id in 138 aa, and to Vibrio cholerae hypothetical protein VC2434 TR:Q9KPD6 (EMBL:AE004313) (148 aa) fasta scores: E(): 1.6e-26, 49.3% id in 140 aa.
  
  
 0.911
YPO0144
Putative hydrolase; Similar to Escherichia coli ADP compounds hydrolase NudE SW:NUDE_ECOLI (P45799) (186 aa) fasta scores: E(): 0,74.7% id in 178 aa.
  
  
  0.909
b4383
Thymidine phosphorylase (pseudogene); Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
    
  0.902
pgm
Phosphoglucomutase; Similar to Escherichia coli phosphoglucomutase Pgm SW:PGMU_ECOLI (P36938) (546 aa) fasta scores: E(): 0, 82.8% id in 546 aa, and to Vibrio cholerae phosphoglucomutase VC2095 TR:Q9KQA5 (EMBL:AE004283) (548 aa) fasta scores: E(): 0, 69.6% id in 546 aa.
   
 
  0.902
ubiX
Probable 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.
     
  0.897
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
 0.782
icc
Icc protein homologue; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
 
  
 0.771
bioR
Bifunctional protein BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
   
    0.736
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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