STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptsPSimilar to Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsP SW:PT1P_ECOLI (P37177) (748 aa) fasta scores: E(): 0, 79.3% id in 747 aa, and to Vibrio cholerae phosphoenolpyruvate-protein phosphotransferase VC0672 TR:Q9KU52 (EMBL:AE004153) (748 aa) fasta scores: E(): 0,51.2% id in 752 aa. Escherichia coli protein also possesses a putative sensory transduction domain and is possible transcriptional regulator; Belongs to the PEP-utilizing enzyme family. (748 aa)    
Predicted Functional Partners:
npr
Similar to Escherichia coli phosphocarrier protein Npr SW:PTSO_ECOLI (P33996) (90 aa) fasta scores: E(): 1.2e-29, 87.8% id in 90 aa, and to Klebsiella pneumoniae phosphocarrier protein Npr SW:PTSO_KLEPN (P51185) (90 aa) fasta scores: E(): 1.1e-28, 82.2% id in 90 aa.
  
 
 0.997
fpr-2
Fpr protein; Similar to Salmonella typhimurium PTS system,fructose-specific IIa/FPr component FruB SW:PTFA_SALTY (P17127) (376 aa) fasta scores: E(): 0, 71.0% id in 376 aa,and to Escherichia coli PTS system, fructose-specific IIa/FPr component FruB SW:PTFA_ECOLI (P24217) (376 aa) fasta scores: E(): 0, 69.4% id in 376 aa.
 
 0.983
hpr
Probable phosphocarrier protein component of a phosphoenolpyruvate-dependent phosphotransferase system (PTS). Similar to Escherichia coli and Salmonella typhimurium phosphocarrier protein PtsH SW:PTHP_ECOLI (P07006) (85 aa) fasta scores: E(): 4.9e-30, 97.6% id in 85 aa, and to Klebsiella pneumoniae phosphocarrier protein PtsH SW:PTHP_KLEPN (P16481) (85 aa) fasta scores: E(): 8e-30, 96.5% id in 85 aa.
  
 
 0.910
YPO0405
Similar to e.g. Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsI,SW:PT1_ECOLI (P08839) (575 aa) fasta scores: E(): 0, 36.0% id in 583 aa, but has both N- and C-terminal extensions. Also similar to Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsA,SW:PT1A_ECOLI (P32670) (711 aa) fasta scores: E(): 0, 64.5% id in 726 aa and to Escherichia coli putative phosphoenolpyruvate-protein phosphotransferase YpdD,SW:YPDD_ECOLI (P77439) (831 aa) fasta scores: E(): 0, 41.5% id in 853 aa.
  
 
0.855
rppH
Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.
  
 
  0.831
crr
Probable glucose-specific IIA component of a phosphoenolpyruvate-dependent phosphotransferase system (PTS). Similar to Salmonella typhimurium PTS system,glucose-specific IIA component Crr SW:PTGA_SALTY (P02908) (168 aa) fasta scores: E(): 0, 94.0% id in 168 aa, and to Escherichia coli PTS system, glucose-specific IIA component Crr SW:PTGA_ECOLI (P08837) (168 aa) fasta scores: E(): 0,92.9% id in 168 aa.
 
     0.806
ptsN
Probable sigma (54) modulation protein (pseudogene); Pfam match to entry PF02482 Ribosomal_S30, score 45.80, E-value 9.7e-10.
  
   
 0.728
YPO0787
Hypothetical protein; Doubtful CDS with no significant database hits.
       0.683
YPO0788
Hypothetical protein; Doubtful CDS with no significant database hits.
       0.683
metH
5-Methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
  0.620
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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