STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
YPO0804Putative regulatory membrane protein; Similar to Vibrio cholerae toxin corregulated pilus biosynthesis protein TcpP SW:TCPP_VIBCH (P29485) (221 aa) fasta scores: E(): 1.5e-05, 28.7% id in 181 aa, N-terminus is similar to the N-terminus of Vibrio fischeri transmembrane transcriptional activator ToxR TR:Q56689 (EMBL:L29053) (316 aa) fasta scores: E(): 8.5e-05, 36.6% id in 101 aa. (238 aa)    
Predicted Functional Partners:
YPO0803
Hypothetical protein; No significant database hits.
       0.773
YPO2884
Putative exported protein; No significant database matches.
  
     0.606
YPO1192
Conserved hypothetical protein; Weakly similar to others of unknown function Bacillus halodurans BH2933 protein BH2933 TR:Q9K8S0 (EMBL:AP001517) (269 aa) fasta scores: E(): 2e-09, 26.8% id in 284 aa, and to Nostoc sp. GSV224 hypothetical protein TR:Q9RAH0 (EMBL:AF204805) (265 aa) fasta scores: E(): 0.12,22.3% id in 292 aa.
  
     0.548
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.536
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
    
 0.505
fliT
FliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
  
     0.505
cysG-2
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
    
 0.505
plaA
Similar to Yersinia enterocolitica phospholipase A YplA TR:O85477 (EMBL:AF067849) (324 aa) fasta scores: E(): 0, 69.0% id in 326 aa, and to Serratia sp MK1 phospholipase A1 PlaA TR:Q9X9D8 (EMBL:U37262) (320 aa) fasta scores: E(): 0, 57.5% id in 322 aa.
  
     0.485
cld
Similar to Yersinia pseudotuberculosis chain length determinant Cld or Wzz TR:Q56932 (EMBL:U13685) (383 aa) fasta scores: E(): 0, 98.7% id in 383 aa, and identical to the previously sequenced Yersinia pestis O-antigen chain length determinant-like protein Wzz TR:Q9RCC2 (EMBL:AJ251713) (383 aa) fasta scores: E(): 0, 100.0% id in 383 aa.
  
     0.481
sepC
Insecticial toxin; Similar to Serratia entomophila plasmid pADAP virulence protein SepC TR:AAG09644 (EMBL:AF135182) (973 aa) fasta scores: E(): 0, 73.6% id in 987 aa, to Photorhabdus luminescens insecticidal toxin complex protein TccC TR:O85157 (EMBL:AF047028) (1043 aa) fasta scores: E(): 0,54.8% id in 825 aa, and to Yersinia pestis YPO2312 putative insecticidal toxin complex (874 aa) fasta scores: E(): 0,64.9% identity in 880 aa overlap, YPO3674 (1011 aa) fasta scores: E(): 0, 51.4% identity in 699 aa overlap and YPO3673 (952 aa) fasta scores: E(): 0, 52.2% identity in 696 aa overlap. [...]
  
     0.479
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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