Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
YPO0940Conserved hypothetical protein; Similar to Pseudomonas aeruginosa twitching mobility protein PilT SW:PILT_PSEAE (P24559) (344 aa) fasta scores: E(): 0, 45.2% id in 330 aa, and to Escherichia coli hypothetical protein YggR SW:YGGR_ECOLI (P52052) (326 aa) fasta scores: E(): 0, 56.3% id in 325 aa. (358 aa)    
Predicted Functional Partners:
YPO0806
Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
   
 0.885
hofC
Putative type II secretion system protein; Similar to Escherichia coli protein transport protein HofC or HopC SW:HOFC_ECOLI (P36646) (400 aa) fasta scores: E(): 0, 38.9% id in 398 aa, and to Pseudomonas aeruginosa fimbrial assembly protein PilC SW:PILC_PSEAE (P22609) (406 aa) fasta scores: E(): 0, 34.2% id in 401 aa.
 
  
 0.885
YPO0150
Putative membrane transport protein; Similar to Haemophilus influenzae competence protein E precursor ComE or HI0435 SW:COME_HAEIN (P31772) (445 aa) fasta scores: E(): 0, 42.1% id in 387 aa, and to Escherichia coli protein transport protein hofQ precursor SW:HOFQ_ECOLI (P34749) (412 aa) fasta scores: E(): 0, 48.6% id in 381 aa. Note the differing N-terminal region and the low G+C content of the upstream DNA region.
 
   
 0.817
YPO0813
Similar to Erwinia carotovora general secretion pathway protein G OutG SW:GSPG_ERWCA (P31586) (156 aa) fasta scores: E(): 0, 69.9% id in 133 aa, and to Erwinia chrysanthemi general secretion pathway protein G OutG SW:GSPG_ERWCH (P31585) (153 aa) fasta scores: E(): 0, 67.9% id in 134 aa.
 
  
 0.665
nifJ
Similar to Escherichia coli probable pyruvate-flavodoxin oxidoreductase YdbK SW:NIFJ_ECOLI (P52647) (1174 aa) fasta scores: E(): 0, 80.5% id in 1177 aa, and to Klebsiella pneumoniae pyruvate-flavodoxin oxidoreductase NifJ SW:NIFJ_KLEPN (P03833) (1171 aa) fasta scores: E(): 0, 48.0% id in 1184 aa.
  
    0.642
YPO1394
Putative membrane protein; Similar to Neisseria gonorrhoeae competence protein ComA SW:COMA_NEIGO (P51973) (691 aa) fasta scores: E(): 1.8e-27, 28.9% id in 714 aa, and to Escherichia coli hypothetical protein YcaI SW:YCAI_ECOLI (P37443) (780 aa) fasta scores: E(): 0, 41.9% id in 756 aa.
 
   
 0.623
YPO0941
Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
       0.616
YPO0147
Putative membrane protein; Similar to Haemophilus influenzae competence protein B ComB SW:COMB_HAEIN (P31769) (168 aa) fasta scores: E(): 0.018, 26.6% id in 169 aa and to Escherichia coli hypothetical protein YrfC SW:YRFC_ECOLI (P45752) (179 aa) fasta scores: E(): 2.7e-07, 25.7% id in 179 aa.
  
  
 0.524
YPO0816
Similar to Klebsiella pneumoniae general secretion pathway protein D GspD SW:GSPD_KLEPN (P15644) (660 aa) fasta scores: E(): 0, 48.9% id in 640 aa, and to Aeromonas salmonicida general secretion pathway protein D ExeD SW:GSPD_AERSA (P45778) (678 aa) fasta scores: E(): 0, 47.1% id in 633 aa. The CDS contains an internal deletion relative to other orthologues around codon 380. The effect on function is unknown.
 
   
 0.520
barA
Two-component regulatory protein; Similar to Escherichia coli sensor protein BarA SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 61.6% id in 928 aa, and to Erwinia carotovora subsp. carotovora sensor/regulator protein RpfA TR:O08235 (EMBL:U62023) (929 aa) fasta scores: E(): 0, 59.7% id in 938 aa.
     
 0.480
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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